在英文中，可以使用以下表达来表示某人感到非常疲倦：
He feels extremely tired.
He feels very exhausted.
He feels utterly drained.
其中，tired 表示疲倦，exhausted 表示精疲力竭，drained 表示耗尽体力。
举例：
He's been working all day and he feels extremely tired now. 他整天都在工作，现在感到非常疲倦。
The marathon left him feepng very exhausted. 马拉松让他感到非常精疲力竭。
The long fpght drained him of all his energy. 长途飞行使他耗尽了所有体力。