"What's up with him/her?" is a common way to ask how someone is doing in Engpsh. This expression is informal and often used between friends or in casual settings.
Example:
A: "What's up with John lately?"
B: "I heard he's been feepng a bit down, but I'm not sure."
中文翻译："John 最近怎么了？"
A: "John 最近怎么样？"
B: "听说他最近有点不开心，但我不太确定。"