"你怎么了"在英语中可以表达为 "What's wrong with you?" 或 "What's the matter with you?"。
"What's wrong with you?" 来自于英语中常用的疑问句型"What's + noun/pronoun + with + pronoun/noun?"，它的意思是询问对方出了什么问题。
例句：
What's wrong with you? 你怎么了？
What's the matter with you? 你怎么了？
"What's the matter with you?" 其实和上面的“What's wrong with you” 意思是一样的。
例句：
What's the matter with you? 你怎么了？
What's the matter? 你怎么了？