He set out from home.
来源：set out 的意思是“出发，开始”，from home 则表示“从家”。
例句：
He set out from home at 6 o'clock in the morning. 他早上六点从家出发。
I set out from home early to avoid the traffic. 我早早地从家出发，以避免交通堵塞。
They set out from home on a journey to visit their grandparents. 他们从家出发去拜访祖父母。